In the all-new Aliens vs. Predator players will have the chance to take the role of the three infamous species; the Colonial Marine, the Predator and the Alien. Each of the three species has its very own distinct story-driven single-player campaign mode that interweaves with the campaigns of the other two species. Aliens vs. Predator will also feature unique 3-way online multiplayer, allowing gamers to pit the three species against each other in the ultimate battle for survival and for the right to be crowned the deadliest species.

On planet BG-386 a colonist mining group discovers an ancient pyramid containing a dark and horrible secret. Across the stars a race of warriors is alerted to the discovery of their pyramid and a hunting party is dispatched to ensure that it remains sealed at all costs, whilst deep inside the ruined pyramid a malevolent intelligence awakes from centuries of dormancy.